Births on April 5

Giovanni dalle Bande Nere, Italian condottiero (d. 1526)

Lodovico de' Medici, also known as Giovanni delle Bande Nere (6 April 1498 – 30 November 1526) was an Italian condottiero.

20 May

Discovery of the sea route to India
Portuguese explorer Vasco da Gama discovers the sea route to India when he arrives at Kozhikode (previously known as Calicut), India.
31 Jul

Trinidad
On his third voyage to the Western Hemisphere, Christopher Columbus becomes the first European to discover the island of Trinidad.
26 Aug

Pietà (Michelangelo)
Michelangelo is commissioned to carve the Pietà.