Byzantine Emperor Basiliscus issues a circular letter (Enkyklikon) to the bishops of his empire, supporting the Monophysite christological position.

Flavius Basiliscus (Greek: , Basilskos; died 476/477) was Eastern Roman emperor from 9 January 475 to August 476. He became magister militum per Thracias in 464, under his brother-in-law, Emperor Leo (r. 457474). Basiliscus commanded the army for an invasion of the Vandal Kingdom in 468, which was defeated at the Battle of Cape Bon. There were accusations at the time that Basiliscus was bribed by Aspar, the magister militum; many historians dismiss this, instead concluding that Basiliscus was either incompetent or foolish for accepting Vandal King Gaiseric's offer of a truce, which the latter used to construct fireships. Basiliscus's defeat cost the Eastern Empire 130,000 pounds (59,000 kg) of gold, causing the empire to hover above bankruptcy for 30 years. When Basiliscus returned to Constantinople, he sought refuge in the Church of St. Sophia. His sister, Empress Verina, secured him a pardon and he left the church to retire in Neapolis.

When Emperor Leo died in 474, his grandson Emperor Leo II (r. 474) took power, but soon died; his father, Zeno (r. 474475, 476491) ascended the throne in the same year, in a politically precarious position. Verina conspired to install the magister officiorum Patricius, her lover, as emperor. This plot was supported by Basiliscus, who succeeded in recruiting Isaurian brothers Illus and Trocundes, as well as Verina's nephew Armatus. Zeno fled on 9 January 475, either after learning of the plot or after Verina warned him that his life was in danger. Although Patricius was Verina's intended successor, Basiliscus convinced the Eastern Roman Senate to acclaim him instead.

Basiliscus quickly lost the support of the people after a combination of heavy taxes, heretical policies, and a natural disaster viewed as divine wrath for said heretical views. In an attempt to increase support, he embraced the miaphysites, restoring Timothy Ailuros as the Patriarch of Alexandria and Peter the Fuller as Patriarch of Antioch. He heeded their advice and issued an encyclical on 9 April 475 which promoted the first three ecumenical councils of the church: Nicaea, Constantinople, and Ephesus, and condemned the Council of Chalcedon and the Tome of Leo. The Patriarch of Constantinople, Acacius, strongly opposed him, and together with Daniel the Stylite, turned the population of Constantinople against Basiliscus.

Basiliscus quickly lost his allies, losing Verina almost immediately as a consequence of executing Patricius. Illus and Trocundes, who were besieging Zeno in his homeland of Isauria, were convinced by Zeno to defect, and soon the three of them marched their troops toward the capital. Hearing this, Basiliscus ordered Armatus to take a number of troops and intercept them. Armatus betrayed Basiliscus after Zeno promised him the position of magister militum praesentalis for life, and that his son, Basiliscus, would be made caesar (title). Armatus then directed his army away from the road which Zeno was traveling along, allowing Zeno to enter Constantinople unopposed in August 476. Basiliscus and his family hid in a church until Zeno promised not to execute them, and they were exiled to Limnae in Cappadocia, where they were either beheaded or imprisoned in a dried-up cistern and left to starve to death.

This is a list of the Byzantine emperors from the foundation of Constantinople in 330 AD, which marks the conventional start of the Byzantine Empire (or the Eastern Roman Empire), to its fall to the Ottoman Empire in 1453 AD. Only the emperors who were recognized as legitimate rulers and exercised sovereign authority are included, to the exclusion of junior co-emperors (symbasileis) who never attained the status of sole or senior ruler, as well as of the various usurpers or rebels who claimed the imperial title.

The following list starts with Constantine the Great, the first Christian emperor, who rebuilt the city of Byzantium as an imperial capital, Constantinople, and who was regarded by the later emperors as the model ruler. It was under Constantine that the major characteristics of what is considered the Byzantine state emerged: a Roman polity centered at Constantinople and culturally dominated by the Greek East, with Christianity as the state religion.

The Byzantine Empire was the direct legal continuation of the eastern half of the Roman Empire following the division of the Roman Empire in 395. Emperors listed below up to Theodosius I in 395 were sole or joint rulers of the entire Roman Empire. The Western Roman Empire continued until 476. Byzantine emperors considered themselves to be rightful Roman emperors in direct succession from Augustus; the term "Byzantine" was coined by Western historiography only in the 16th century. The use of the title "Roman Emperor" by those ruling from Constantinople was not contested until after the Papal coronation of the Frankish Charlemagne as Holy Roman Emperor (25 December 800), done partly in response to the Byzantine coronation of Empress Irene, whose claim, as a woman, was not recognized by Pope Leo III.

In practice, according to the Hellenistic political system, the Byzantine emperor had been given total power through God to shape the state and its subjects, he was the last authority and legislator of the empire and all his work was in imitation of the sacred kingdom of God, also according to the Christian principles,he was the ultimate benefecator and protector of his people.