San Bernardino attack: Syed Rizwan Farook and Tashfeen Malik kill 14 people and wound 22 at the Inland Regional Center in San Bernardino, California.

Sayyid (UK: , US: ; Arabic: [sjjd]; Persian: [sejjed]; meaning 'sir', 'Lord', 'Master'; Arabic plural: sdah; feminine: sayyidah; Persian: [sejjede]) is an honorific title denoting people accepted as descendants of the Islamic prophet Muhammad through his grandsons, Hasan ibn Ali and Husayn ibn Ali,:31 sons of Muhammad's daughter Fatima and his cousin and son-in-law Ali (Ali ibn Abi Talib).:149Female sayyids are given the titles sayyida, syeda, alawiyah or sharifa. In some regions of the Islamic world, such as in India, the descendants of Muhammad are given the title amr or mr, meaning "commander", "general". In Shia Islam the son of a non Sayyid father and a Sayyida mother claim the title Mirza, whereas in Sunni Islam a son of a non Sayyid father and a Sayyida mother can claim the title Sayyid or Sharif fulfilling special requirements.Although not verified, many Arabic language experts state that it has its roots in the word al-asad , meaning "lion", probably because of the qualities of valour and leadership.:158:265Although reliable statistics are unavailable, conservative estimates put the number of Sayyids in the tens of millions.In the Arab world, sayyid is the equivalent of the English word "liege lord" or "master" when referring to a descendant of Muhammad, as in Sayyid Ali Sultan. The word sidi (from the contracted form sayyid, "my liege") is often used in Arabic.Another term with a very similar meaning is Sharf.

On December 2, 2015, a terrorist attack, consisting of a mass shooting and an attempted bombing, occurred at the Inland Regional Center in San Bernardino, California. The perpetrators, Syed Rizwan Farook and Tashfeen Malik, a married couple living in the city of Redlands, targeted a San Bernardino County Department of Public Health training event and Christmas party of about 80 employees in a rented banquet room. 14 people were killed and 22 others were seriously injured. Farook was a U.S.-born citizen of Pakistani descent, who worked as a health department employee. Malik was a Pakistani-born green card holder.

After the shooting, the couple fled in a rented Ford Expedition sport utility vehicle (SUV). Four hours later, police pursued their vehicle and killed them in a shootout, which also left two officers injured.

According to the FBI's investigation, the perpetrators were "homegrown violent extremists" inspired by foreign terrorist groups. They were not directed by such groups and were not part of any terrorist cell or network. FBI investigators have said that Farook and Malik had become radicalized over several years prior to the attack, consuming "poison on the internet" and expressing a commitment to jihadism and martyrdom in private messages to each other. Farook and Malik had traveled to Saudi Arabia in the years before the attack. The couple had amassed a large stockpile of weapons, ammunition, and bomb-making equipment in their home.

Enrique Marquez Jr., a friend and former neighbor of Farook's, was investigated in connection with his purchase of the two rifles used in the attack. Marquez was arrested in December 2015, and later pleaded guilty to federal charges of providing material support for terrorism and making false statements in connection with the acquisition of a firearm. Marquez also admitted that, in 2011, he conspired with Farook to carry out shooting and bombing attacks, plans which were abandoned at the time. Three other people, including Farook's brother and sister-in-law, were arrested for immigration fraud in connection with a sham marriage between Marquez and Mariya Chernykh (the sister-in-law of Farook's brother). All three pleaded guilty.

The attack was the deadliest mass shooting in the U.S. since the 2012 Sandy Hook Elementary School shooting, and the deadliest terrorist attack to occur in the U.S. since the September 11 attacks. It was surpassed by the Orlando nightclub shooting in June 2016.