Space Shuttle program: STS-61: NASA launches the Space Shuttle Endeavour on a mission to repair the Hubble Space Telescope.

The National Aeronautics and Space Administration (NASA ) is an independent agency of the US federal government responsible for the civil space program, aeronautics research, and space research.NASA was established in 1958, succeeding the National Advisory Committee for Aeronautics (NACA), to give the US space development effort a distinctly civilian orientation, emphasizing peaceful applications in space science. Since its establishment, most American space exploration efforts have been led by NASA, including the Apollo Moon landing missions, the Skylab space station, and later the Space Shuttle. NASA is supporting the International Space Station and is overseeing the development of the Orion spacecraft, the Space Launch System, Commercial Crew vehicles, and the planned Lunar Gateway space station. The agency is also responsible for the Launch Services Program, which provides oversight of launch operations and countdown management for uncrewed NASA launches.

NASA's science is focused on better understanding Earth through the Earth Observing System; advancing heliophysics through the efforts of the Science Mission Directorate's Heliophysics Research Program; exploring bodies throughout the Solar System with advanced robotic spacecraft such as New Horizons; and researching astrophysics topics, such as the Big Bang, through the Great Observatories and associated programs.

The Space Shuttle program was the fourth human spaceflight program carried out by the U.S. National Aeronautics and Space Administration (NASA), which accomplished routine transportation for Earth-to-orbit crew and cargo from 1981 to 2011. Its official name, Space Transportation System (STS), was taken from a 1969 plan for a system of reusable spacecraft of which it was the only item funded for development.The Space Shuttle—composed of an orbiter launched with two reusable solid rocket boosters and a disposable external fuel tank—carried up to eight astronauts and up to 50,000 lb (23,000 kg) of payload into low Earth orbit (LEO). When its mission was complete, the orbiter would reenter the Earth's atmosphere and land like a glider at either the Kennedy Space Center or Edwards Air Force Base.

The Shuttle is the only winged crewed spacecraft to have achieved orbit and landing, and the first reusable crewed space vehicle that has made multiple flights into orbit. Its missions involved carrying large payloads to various orbits including the International Space Station (ISS), providing crew rotation for the space station, and performing service missions on the Hubble Space Telescope. The orbiter also recovered satellites and other payloads (e.g., from the ISS) from orbit and returned them to Earth, though its use in this capacity was rare. Each vehicle was designed with a projected lifespan of 100 launches, or 10 years' operational life. Original selling points on the shuttles were over 150 launches over a 15-year operational span with a 'launch per month' expected at the peak of the program, but extensive delays in the development of the International Space Station never created such a peak demand for frequent flights.