A U.S. MQ-1 Predator is shot down by an Iraqi MiG-25 in the first combat engagement between a drone and conventional aircraft.

The Mikoyan-Gurevich MiG-25 (Russian: -25; NATO reporting name: Foxbat) is a supersonic interceptor and reconnaissance aircraft that is among the fastest military aircraft to enter service. Designed by the Soviet Union's Mikoyan-Gurevich bureau, it is one of the few combat aircraft built primarily using stainless steel. It was to be the last plane designed by Mikhail Gurevich, before his retirement.The first prototype flew in 1964 and the aircraft entered service in 1970. It has an operational top speed of Mach 2.83. Although its thrust was sufficient to reach Mach 3.2+, its speed was limited to prevent engines from overheating at higher air speeds and possibly damaging them beyond repair. The MiG-25 features a powerful radar and four air-to-air missiles and was theoretically capable of a ceiling of 27 km (89,000 ft). When first seen in reconnaissance photography, the large wings suggested an enormous and highly maneuverable fighter, at a time when U.S. design theories were also evolving towards higher maneuverability due to combat performance in the Vietnam War. The appearance of the MiG-25 sparked serious concern in the West and prompted dramatic increases in performance for the McDonnell Douglas F-15 Eagle, then under development in the late 1960s. The capabilities of the MiG-25 were better understood by the West in 1976 when Soviet pilot Viktor Belenko defected in a MiG-25 to the United States via Japan. It turned out that the aircraft's weight necessitated its large wings.

Production of the MiG-25 series ended in 1984 after completion of 1,186 aircraft. A symbol of the Cold War, the MiG-25 flew with Soviet allies and former Soviet republics, remaining in limited service in several export customers. It is one of the highest-flying military aircraft, one of the fastest serially produced interceptor aircraft, and the second-fastest serially produced aircraft after the SR-71 reconnaissance aircraft, which was built in very small series compared to the MiG-25. As of 2018, the MiG-25 remains the fastest manned serially produced aircraft in operational use and the fastest plane that was offered for supersonic flights and edge-of-space flights to civilian customers.

The General Atomics MQ-1 Predator is an American remotely piloted aircraft (RPA) built by General Atomics that was used primarily by the United States Air Force (USAF) and Central Intelligence Agency (CIA). Conceived in the early 1990s for aerial reconnaissance and forward observation roles, the Predator carries cameras and other sensors. It was modified and upgraded to carry and fire two AGM-114 Hellfire missiles or other munitions. The aircraft entered service in 1995, and saw combat in the war in Afghanistan, Pakistan, the NATO intervention in Bosnia, 1999 NATO bombing of Yugoslavia, the Iraq War, Yemen, the 2011 Libyan civil war, the 2014 intervention in Syria, and Somalia.

The USAF describes the Predator as a "Tier II" MALE UAS (medium-altitude, long-endurance unmanned aircraft system). The UAS consists of four aircraft or "air vehicles" with sensors, a ground control station (GCS), and a primary satellite link communication suite. Powered by a Rotax engine and driven by a propeller, the air vehicle can fly up to 400 nmi (460 mi; 740 km) to a target, loiter overhead for 14 hours, then return to its base.

The RQ-1 Predator was the primary remotely piloted aircraft used for offensive operations by the USAF and the CIA in Afghanistan and the Pakistani tribal areas from 2001 until the introduction of the MQ-9 Reaper; it has also been deployed elsewhere. Because offensive uses of the Predator are classified by the U.S., U.S. military officials have reported an appreciation for the intelligence and reconnaissance-gathering abilities of RPAs but declined to publicly discuss their offensive use. The United States Air Force retired the Predator in 2018, replacing it with the Reaper.Civilian applications for drones have included border enforcement and scientific studies, and to monitor wind direction and other characteristics of large forest fires (such as the drone that was used by the California Air National Guard in the August 2013 Rim Fire).