Plutonium is first produced and isolated by Dr. Glenn T. Seaborg.

Glenn Theodore Seaborg (; April 19, 1912 February 25, 1999) was an American chemist whose involvement in the synthesis, discovery and investigation of ten transuranium elements earned him a share of the 1951 Nobel Prize in Chemistry. His work in this area also led to his development of the actinide concept and the arrangement of the actinide series in the periodic table of the elements.

Seaborg spent most of his career as an educator and research scientist at the University of California, Berkeley, serving as a professor, and, between 1958 and 1961, as the university's second chancellor. He advised ten US Presidentsfrom Harry S. Truman to Bill Clintonon nuclear policy and was Chairman of the United States Atomic Energy Commission from 1961 to 1971, where he pushed for commercial nuclear energy and the peaceful applications of nuclear science. Throughout his career, Seaborg worked for arms control. He was a signatory to the Franck Report and contributed to the Limited Test Ban Treaty, the Nuclear Non-Proliferation Treaty and the Comprehensive Test Ban Treaty. He was a well-known advocate of science education and federal funding for pure research. Toward the end of the Eisenhower administration, he was the principal author of the Seaborg Report on academic science, and, as a member of President Ronald Reagan's National Commission on Excellence in Education, he was a key contributor to its 1983 report "A Nation at Risk".

Seaborg was the principal or co-discoverer of ten elements: plutonium, americium, curium, berkelium, californium, einsteinium, fermium, mendelevium, nobelium and element 106, which, while he was still living, was named seaborgium in his honor. He said about this naming, "This is the greatest honor ever bestowed upon me--even better, I think, than winning the Nobel Prize. Future students of chemistry, in learning about the periodic table, may have reason to ask why the element was named for me, and thereby learn more about my work." He also discovered more than 100 isotopes of transuranium elements and is credited with important contributions to the chemistry of plutonium, originally as part of the Manhattan Project where he developed the extraction process used to isolate the plutonium fuel for the second atomic bomb. Early in his career, he was a pioneer in nuclear medicine and discovered isotopes of elements with important applications in the diagnosis and treatment of diseases, including iodine-131, which is used in the treatment of thyroid disease. In addition to his theoretical work in the development of the actinide concept, which placed the actinide series beneath the lanthanide series on the periodic table, he postulated the existence of super-heavy elements in the transactinide and superactinide series.

After sharing the 1951 Nobel Prize in Chemistry with Edwin McMillan, he received approximately 50 honorary doctorates and numerous other awards and honors. The list of things named after Seaborg ranges from the chemical element seaborgium to the asteroid 4856 Seaborg. He was a prolific author, penning numerous books and 500 journal articles, often in collaboration with others. He was once listed in the Guinness Book of World Records as the person with the longest entry in Who's Who in America.

Plutonium is a radioactive chemical element with the symbol Pu and atomic number 94. It is an actinide metal of silvery-gray appearance that tarnishes when exposed to air, and forms a dull coating when oxidized. The element normally exhibits six allotropes and four oxidation states. It reacts with carbon, halogens, nitrogen, silicon, and hydrogen. When exposed to moist air, it forms oxides and hydrides that can expand the sample up to 70% in volume, which in turn flake off as a powder that is pyrophoric. It is radioactive and can accumulate in bones, which makes the handling of plutonium dangerous.

Plutonium was first synthetically produced and isolated in late 1940 and early 1941, by a deuteron bombardment of uranium-238 in the 1.5-metre (60 in) cyclotron at the University of California, Berkeley. First, neptunium-238 (half-life 2.1 days) was synthesized, which subsequently beta-decayed to form the new element with atomic number 94 and atomic weight 238 (half-life 88 years). Since uranium had been named after the planet Uranus and neptunium after the planet Neptune, element 94 was named after Pluto, which at the time was considered to be a planet as well. Wartime secrecy prevented the University of California team from publishing its discovery until 1948.

Plutonium is the element with the highest atomic number to occur in nature. Trace quantities arise in natural uranium-238 deposits when uranium-238 captures neutrons emitted by decay of other uranium-238 atoms.

Both plutonium-239 and plutonium-241 are fissile, meaning that they can sustain a nuclear chain reaction, leading to applications in nuclear weapons and nuclear reactors. Plutonium-240 exhibits a high rate of spontaneous fission, raising the neutron flux of any sample containing it. The presence of plutonium-240 limits a plutonium sample's usability for weapons or its quality as reactor fuel, and the percentage of plutonium-240 determines its grade (weapons-grade, fuel-grade, or reactor-grade). Plutonium-238 has a half-life of 87.7 years and emits alpha particles. It is a heat source in radioisotope thermoelectric generators, which are used to power some spacecraft. Plutonium isotopes are expensive and inconvenient to separate, so particular isotopes are usually manufactured in specialized reactors.

Producing plutonium in useful quantities for the first time was a major part of the Manhattan Project during World War II that developed the first atomic bombs. The Fat Man bombs used in the Trinity nuclear test in July 1945, and in the bombing of Nagasaki in August 1945, had plutonium cores. Human radiation experiments studying plutonium were conducted without informed consent, and several criticality accidents, some lethal, occurred after the war. Disposal of plutonium waste from nuclear power plants and dismantled nuclear weapons built during the Cold War is a nuclear-proliferation and environmental concern. Other sources of plutonium in the environment are fallout from numerous above-ground nuclear tests, now banned.