Seventy years of Holy See-United States relations are ended by a Congressional ban on federal funding of diplomatic envoys to the Vatican and are not restored until January 10, 1984.

The principal United States official is Chargé d'Affaires Patrick Connell, who officially started at his position on January 20, 2021. The Holy See is represented by its apostolic nuncio, Archbishop Christophe Pierre, who assumed office on April 12, 2016. The U.S. Embassy to the Holy See is located in Rome, in the Villa Domiziana. The Nunciature to the United States is located in Washington, D.C., at 3339 Massachusetts Avenue, N.W.