Roanoke Colony: A second group of English settlers arrives on Roanoke Island off North Carolina to re-establish the deserted colony.

The establishment of the Roanoke Colony (; ROH-ə-nohk) was an attempt by Sir Walter Raleigh to found the first permanent English settlement in North America. The English, led by Sir Humphrey Gilbert, had claimed St. John's, Newfoundland, in 1583 as the first English territory in North America at the royal prerogative of Queen Elizabeth I. The first Roanoke colony was founded by governor Ralph Lane in 1585 on Roanoke Island in what is now Dare County, North Carolina, United States.(pp 45, 54–59) Following the failure of the 1585 settlement, a second expedition, led by John White, landed on the same island in 1587, and set up another settlement that became known as the Lost Colony due to the subsequent unexplained disappearance of its population.(pp xx, 89, 276)Lane's colony was troubled by a lack of supplies and poor relations with the local Native Americans. While awaiting a delayed resupply mission by Sir Richard Grenville, Lane abandoned the colony and returned to England with Sir Francis Drake in 1586. Grenville arrived two weeks later and also returned home, leaving behind a small detachment to protect Raleigh's claim.(pp 70–77)In 1587, Raleigh sent White on an expedition to establish the "Cittie of Raleigh" in Chesapeake Bay. During a stop to check on Grenville's men, flagship pilot Simon Fernandes forced White's colonists to remain on Roanoke.(pp 81–82, 89) White, however, returned to England with Fernandes, intending to bring more supplies back to his colony in 1588.(pp 93–94) The Anglo-Spanish War delayed White's return to Roanoke until 1590,(pp 94, 97) and upon his arrival he found the settlement fortified but abandoned. The cryptic word "CROATOAN" was found carved into the palisade, which White interpreted to mean the colonists had relocated to Croatoan Island. Before he could follow this lead, rough seas and a lost anchor forced the rescue mission to return to England.(pp 100–03)The fate of the approximately 112–121 colonists remains unknown. Speculation that they had assimilated with nearby Native American communities appears in writings as early as 1605.(pp 113–114) Investigations by the Jamestown colonists produced reports that the Roanoke settlers had been massacred, as well as stories of people with European features in Native American villages, but no hard evidence was produced.(pp 116–125) Interest in the matter fell into decline until 1834, when George Bancroft published his account of the events in A History of the United States. Bancroft's description of the colonists, particularly White's infant granddaughter Virginia Dare, cast them as foundational figures in American culture, and captured the public imagination.(pp 128–130) Despite this renewed interest, modern research has failed to find archaeological evidence to explain the disappearance of the colonists.(p 270)