Holocaust: Germany liquidates the Jewish Ghetto in Brzeżany, Poland (now Berezhany, Ukraine). Around 1,180 Jews are led to the city's old Jewish graveyard and shot.

In the Jewish diaspora, a Jewish quarter (also known as jewry, juiverie, Judengasse, Jewynstreet, or proto-ghetto) is the area of a city traditionally inhabited by Jews. Jewish quarters, like the Jewish ghettos in Europe, were often the outgrowths of segregated ghettos instituted by the surrounding Christian authorities. A Yiddish term for a Jewish quarter or neighborhood is "Di yiddishe gas" (Yiddish: ), or "The Jewish quarter." While in Ladino, they are known as maal yahud, meaning "The Jewish quarter".

Many European and Near Eastern cities once had a historical Jewish quarter and some still have it. The history of the Jews in Iraq is documented from the time of the Babylonian captivity c 586 BC. Iraqi Jews constitute one of the world's oldest and most historically significant Jewish communities.

Jewish quarters in Europe existed for a number of reasons. In some cases, Christian authorities wished to segregate Jews from the Christian population so that Christians would not be "contaminated" by them or so as to put psychological pressure on Jews to convert to Christianity. From the Jewish point of view, concentration of Jews within a limited area offered a level of protection from outside influences or mob violence. In many cases, residents had their own justice system. When political authorities designated an area where Jews were required by law to live, such areas were commonly referred to as ghettos, and were usually coupled with many other disabilities and indignities. The areas chosen usually consisted of the most undesirable areas of a city. In the 19th century, Jewish ghettos were progressively abolished, and their walls taken down, though some areas of Jewish concentration continued and continue to exist. In some cities, Jewish quarters refer to areas which historically had concentrations of Jews. For example, many maps of Spanish towns mark a "Jewish Quarter", though Spain hasn't had a significant Jewish population for over 500 years.

However, in the course of World War II, Nazi Germany reestablished Jewish ghettos in Nazi-occupied Europe (which they called Jewish quarters) for the purpose of segregation, persecution, terror, and exploitation of Jews, mostly in Eastern Europe. According to USHMM archives, "The Germans established at least 1,000 ghettos in German-occupied and annexed Poland and the Soviet Union alone."

Nazi Germany, officially known as the German Reich from 1933 until 1943, and the Greater German Reich from 1943 to 1945, was the German state between 1933 and 1945, when Adolf Hitler and the Nazi Party controlled the country, transforming it into a dictatorship. Under Hitler's rule, Germany quickly became a totalitarian state where nearly all aspects of life were controlled by the government. The Third Reich, meaning "Third Realm" or "Third Empire", alluded to the Nazi claim that Nazi Germany was the successor to the earlier Holy Roman Empire (800–1806) and German Empire (1871–1918). The Third Reich, which Hitler and the Nazis referred to as the Thousand Year Reich, ended in May 1945 after just 12 years, when the Allies defeated Germany, ending World War II in Europe.

On 30 January 1933, Hitler was appointed chancellor of Germany, the head of government, by the president of the Weimar Republic, Paul von Hindenburg, the head of state. The Nazi Party then began to eliminate all political opposition and consolidate its power. Hindenburg died on 2 August 1934 and Hitler became dictator of Germany by merging the offices and powers of the chancellery and presidency. A national referendum held 19 August 1934 confirmed Hitler as sole Führer (leader) of Germany. All power was centralised in Hitler's person and his word became the highest law. The government was not a coordinated, co-operating body, but a collection of factions struggling for power and Hitler's favour. In the midst of the Great Depression, the Nazis restored economic stability and ended mass unemployment using heavy military spending and a mixed economy. Using deficit spending, the regime undertook a massive secret rearmament program, forming the Wehrmacht (armed forces), and constructed extensive public works projects, including the Autobahnen (motorways). The return to economic stability boosted the regime's popularity.

Racism, Nazi eugenics, and especially antisemitism, were central ideological features of the regime. The Germanic peoples were considered by the Nazis to be the master race, the purest branch of the Aryan race. Discrimination and the persecution of Jews and Romani people began in earnest after the seizure of power. The first concentration camps were established in March 1933. Jews and others deemed undesirable were imprisoned, and liberals, socialists, and communists were murdered, imprisoned, or exiled. Christian churches and citizens that opposed Hitler's rule were oppressed and many leaders imprisoned. Education focused on racial biology, population policy, and fitness for military service. Career and educational opportunities for women were curtailed. Recreation and tourism were organised via the Strength Through Joy program, and the 1936 Summer Olympics showcased Germany on the international stage. Propaganda Minister Joseph Goebbels made effective use of film, mass rallies, and Hitler's hypnotic oratory to influence public opinion. The government controlled artistic expression, promoting specific art forms and banning or discouraging others.

From the latter half of the 1930s, Nazi Germany made increasingly aggressive territorial demands, threatening war if these were not met. The Saarland voted by plebiscite to rejoin Germany in 1935, and in 1936 Hitler sent troops into the Rhineland, which had been de-militarized after World War I. Germany seized Austria in the Anschluss of 1938, and demanded and received the Sudetenland region of Czechoslovakia in that same year. In March 1939, the Slovak state was proclaimed and became a client state of Germany, and the German Protectorate of Bohemia and Moravia was established on the remainder of the occupied Czech Lands. Shortly after, Germany pressured Lithuania into ceding the Memel Territory. Germany signed a non-aggression pact with the Soviet Union and invaded Poland on 1 September 1939, launching World War II in Europe. By early 1941, Germany and its European allies in the Axis powers controlled much of Europe. Extended offices of the Reichskommissariat took control of Nazi-conquered areas and a German administration was established in the remainder of Poland. Germany exploited the raw materials and labour of both its occupied territories and its allies.

Genocide, mass murder, and large-scale forced labour became hallmarks of the regime. Starting in 1939, hundreds of thousands of German citizens with mental or physical disabilities were murdered in hospitals and asylums. Einsatzgruppen paramilitary death squads accompanied the German armed forces inside the occupied territories and conducted the genocide of millions of Jews and other Holocaust victims. After 1941, millions of others were imprisoned, worked to death, or murdered in Nazi concentration camps and extermination camps. This genocide is known as the Holocaust.

While the German invasion of the Soviet Union in 1941 was initially successful, the Soviet resurgence and entry of the United States into the war meant that the Wehrmacht lost the initiative on the Eastern Front in 1943 and by late 1944 had been pushed back to the pre-1939 border. Large-scale aerial bombing of Germany escalated in 1944 and the Axis powers were driven back in Eastern and Southern Europe. After the Allied invasion of France, Germany was conquered by the Soviet Union from the east and the other Allies from the west, and capitulated in May 1945. Hitler's refusal to admit defeat led to massive destruction of German infrastructure and additional war-related deaths in the closing months of the war. The victorious Allies initiated a policy of denazification and put many of the surviving Nazi leadership on trial for war crimes at the Nuremberg trials.