The massacre of the population of the Greek island of Chios by soldiers of the Ottoman Empire following an attempted rebellion, depicted by the French artist Eugène Delacroix.

The Chios massacre (in Greek: Η σφαγή της Χίου, Greek pronunciation: [i sfaˈʝi tis ˈçi.u]) was the killing of tens of thousands of Greeks on the island of Chios by Ottoman troops during the Greek War of Independence in 1822. Greeks from neighboring islands had arrived on Chios and encouraged the Chiotes (a common term to refer to the native inhabitants of the island) to join their revolt. In response, Ottoman troops landed on the island and killed thousands. The massacre of Christians provoked international outrage and led to increasing support for the Greek cause worldwide.