The Prince of Anhua rebellion begins when Zhu Zhifan kills all the officials invited to a banquet and declares his intent on ousting the powerful Ming dynasty eunuch Liu Jin during the reign of the Zhengde Emperor.

Zhu Zhifan (simplified Chinese: ; traditional Chinese: ; pinyin: Zh Zhfn; died 1510) was a member of the Ming dynasty's imperial family. He held the title Prince of Anhua from 1492 until 1510; his major power was in central Shaanxi.

The Prince of Anhua rebellion (Chinese: 安化王之亂) or Prince Anhua uprising was a rebellion by Zhu Zhifan, Prince of Anhua and member of the Zhu royal family, against the reign of the Zhengde Emperor from 12 May 1510 to 30 May 1510. The Prince of Anhua revolt was one of two princedom rebellions during Zhengde's rule as emperor of the Ming dynasty, and precedes the Prince of Ning rebellion in 1519.