The Siege of Cuautla during the Mexican War of Independence ends with both sides claiming victory after Mexican rebels under José María Morelos y Pavón abandon the city after 72 days under siege by royalist Spanish troops under Félix María Calleja.

The Siege of Cuautla was a battle of the War of Mexican Independence that occurred from 19 February through 2 May 1812 at Cuautla, Morelos. The Spanish royalist forces loyal to the Spanish, commanded by Félix María Calleja, besieged the town of Cuautla and its Mexican rebel defenders fighting for independence from the Spanish Empire. The rebels were commanded by José María Morelos y Pavón, Hermenegildo Galeana, and Mariano Matamoros. The battle results are disputed, but it is generally agreed that the battle resulted more favorably for the Spanish whose siege was ultimately successful with the Mexican withdrawal on 2 May 1812.The siege had many consequences to the political, military and social environment in the contemporary Viceroyalty of New Spain which was ruled since 1810 by Francisco Xavier Venegas. Calleja was turned from military commander of all central Mexico to the military commander of Mexico City after fears began of an insurgent attack on the capital. Morelos would continue gaining strength, reinforcing his army and taking new cities throughout the south of the country such as Oaxaca and Córdoba. A further consequence came with the rise to the throne of Ferdinand VII of Spain, when Venegas was relieved of his command as viceroy in February 1813.