An earthquake kills about 250,000 people in what is now Syria and Antiochia.

The 526 Antioch earthquake struck Syria and, in particular, the city of Antioch in the Byzantine Empire. It occurred some time in late May 526, probably between 20 and 29 May, during mid-morning, killing approximately 250,000 people. This was in the seventh year of the reign of the Byzantine emperor Justin I and occurred under the consulship of Olybrius. In Antioch the earthquake was followed by a fire that destroyed most of the buildings left standing after the earthquake. The maximum intensity in Antioch is estimated to have been between VIII (Severe) and IX (Violent) on the Mercalli intensity scale.