The L'Innovation department store in Brussels, Belgium, burns down, resulting in 323 dead or missing and 150 injured, the most devastating fire in Belgian history.

The L'Innovation fire was a fire which took place at the À L'Innovation department store on the Rue Neuve/Nieuwstraat in Brussels, Belgium, on 22 May 1967. More than 150 firefighters were mobilised to fight it, 325 people were killed, 80 injured, and the department store itself, the work of the architect Victor Horta, was destroyed.

The L'Innovation fire remains the deadliest fire in Belgian history.