The largest of three earthquakes strikes the island of Rhodes and causes an estimated 30,000 casualties.
The 1481 Rhodes earthquake occurred at 3:00 in the morning on 3 May. It triggered a small tsunami, which caused local flooding. There were an estimated 30,000 casualties. It was the largest of a series of earthquakes that affected Rhodes, starting on 15 March 1481, continuing until January 1482.