Births on May 6

Girolamo Seripando, Italian theologian and cardinal (d. 1563)

Girolamo Seripando (Troja, Apulia, 6 May 1493 – Trento, 17 March 1563) was an Augustinian friar, Italian theologian and cardinal.

15 Feb

Columbus's letter on the first voyage
While on board the Niña, Christopher Columbus writes an open letter (widely distributed upon his return to Portugal) describing his discoveries and the unexpected items he came across in the New World.
4 Mar

Voyages of Christopher Columbus
Explorer Christopher Columbus arrives back in Lisbon, Portugal, aboard his ship Niña from his voyage to what is now The Bahamas and other islands in the Caribbean.
4 May

New World
Pope Alexander VI divides the New World between Spain and Portugal along the Line of Demarcation.
26 Sep

Inter caetera
Pope Alexander VI issues the papal bull Dudum siquidem to the Catholic Monarchs, extending the grant of new lands he made them in Inter caetera.
3 Nov

Dominica
Christopher Columbus first sights the island of Dominica in the Caribbean Sea.