Trần Cảo Rebellion: A group of imperial guards, led by Trịnh Duy Sản, murdered Emperor Lê Tương Dực and fled, leaving the capital Thăng Long undefended.
The Trần Cao rebellion in 1516 is a rebellion in 16th century Vietnam, led by Trần Cao against the Lê dynasty and is regarded as an important factor leading to the collapse of the Early period Lê. It was the second rebellion led against the Lê, following an uprising led by Trần Tuân in 1511.