Deaths on November 22

John Lambert, English Protestant martyr

John Lambert (died 1538) was an English Protestant martyr burnt to death on 22 November 1538 at Smithfield, London.

26 May

John Calvin
Geneva expels John Calvin and his followers from the city. Calvin lives in exile in Strasbourg for the next three years.
25 Jul

Francisco de Orellana
The city of Guayaquil is founded by the Spanish Conquistador Francisco de Orellana and given the name Muy Noble y Muy Leal Ciudad de Santiago de Guayaquil.
6 Aug

Gonzalo Jiménez de Quesada
Bogotá, Colombia, is founded by Gonzalo Jiménez de Quesada.
28 Sep

Battle of Preveza
Ottoman-Venetian War: The Ottoman Navy scores a decisive victory over a Holy League fleet in the Battle of Preveza.
28 Oct

Universidad Santo Tomás de Aquino
The first university in the New World (in present-day Dominican Republic), the Universidad Santo Tomás de Aquino, is established.