Massachusetts enacts the first punitive legislation against the Religious Society of Friends (Quakers). The marriage of church-and-state in Puritanism makes them regard the Quakers as spiritually apostate and politically subversive.

The Puritans were English Protestants in the 16th and 17th centuries who sought to purify the Church of England of Roman Catholic practices, maintaining that the Church of England had not been fully reformed and should become more Protestant. Puritanism played a significant role in English history, especially during the Protectorate.

Puritans were dissatisfied with the limited extent of the English Reformation and with the Church of England's toleration of certain practices associated with the Roman Catholic Church. They formed and identified with various religious groups advocating greater purity of worship and doctrine, as well as personal and corporate piety. Puritans adopted a Reformed theology, and in that sense they were Calvinists (as were many of their earlier opponents). In church polity, some advocated separation from all other established Christian denominations in favour of autonomous gathered churches. These Separatist and Independent strands of Puritanism became prominent in the 1640s, when the supporters of a presbyterian polity in the Westminster Assembly were unable to forge a new English national church.

By the late 1630s, Puritans were in alliance with the growing commercial world, with the parliamentary opposition to the royal prerogative, and with the Scottish Presbyterians with whom they had much in common. Consequently, they became a major political force in England and came to power as a result of the First English Civil War (16421646). Almost all Puritan clergy left the Church of England after the restoration of the monarchy in 1660 and the 1662 Uniformity Act. Many continued to practice their faith in nonconformist denominations, especially in Congregationalist and Presbyterian churches. The nature of the movement in England changed radically, although it retained its character for a much longer period in New England.

Puritanism was never a formally defined religious division within Protestantism, and the term Puritan itself was rarely used after the turn of the 18th century. Some Puritan ideals, including the formal rejection of Roman Catholicism, were incorporated into the doctrines of the Church of England; others were absorbed into the many Protestant denominations that emerged in the late 17th and early 18th centuries in North America and Britain. The Congregational churches, widely considered to be a part of the Reformed tradition, are descended from the Puritans. Moreover, Puritan beliefs are enshrined in the Savoy Declaration, the confession of faith held by the Congregationalist churches.

Massachusetts ( (listen), ), officially the Commonwealth of Massachusetts, is the most populous state in the New England region of the United States. It borders on the Atlantic Ocean and Gulf of Maine to the east, Connecticut to the southwest and Rhode Island to the southeast, New Hampshire to the northeast, Vermont to the northwest, and New York to the west. The capital of Massachusetts is Boston, which is also the most populous city in New England. It is home to the Greater Boston metropolitan area, a region influential upon American history, academia, and industry. Originally dependent on agriculture, fishing and trade, Massachusetts was transformed into a manufacturing center during the Industrial Revolution. During the 20th century, Massachusetts's economy shifted from manufacturing to services. Modern Massachusetts is a global leader in biotechnology, engineering, higher education, finance, and maritime trade.Massachusetts was a site of early English colonization: the Plymouth Colony was founded in 1620 by the Pilgrims of the Mayflower, and in 1630 the Massachusetts Bay Colony, taking its name from the indigenous Massachusett people, established settlements in Boston and Salem. In 1692, the town of Salem and surrounding areas experienced one of America's most infamous cases of mass hysteria, the Salem witch trials. In 1777, General Henry Knox founded the Springfield Armory, which, during the Industrial Revolution, catalyzed numerous important technological advances, including interchangeable parts. In 1786, Shays' Rebellion, a populist revolt led by disaffected American Revolutionary War veterans, influenced the United States Constitutional Convention. In the 18th century, the Protestant First Great Awakening, which swept Britain and the Thirteen Colonies, originated from the pulpit of Northampton preacher Jonathan Edwards. In the late 18th century, Boston became known as the "Cradle of Liberty" for the agitation there that later led to the American Revolution.

The entire Commonwealth of Massachusetts has played a powerful scientific, commercial, and cultural role in the history of the United States. Before the American Civil War, Massachusetts was a center for the abolitionist, temperance, and transcendentalist movements. In the late 19th century, the sports of basketball and volleyball were invented in the western Massachusetts cities of Springfield and Holyoke, respectively. In 2004, Massachusetts became the first U.S. state to legally recognize same-sex marriage as a result of the Massachusetts Supreme Judicial Court's decision in Goodridge v. Department of Public Health. Many prominent American political dynasties have hailed from the state, including the Adams and Kennedy families. Harvard University in Cambridge is the oldest institution of higher learning in the United States, with the largest financial endowment of any university, and Harvard Law School has educated a contemporaneous majority of Justices of the Supreme Court of the United States. Kendall Square in Cambridge has been called "the most innovative square mile on the planet", in reference to the high concentration of entrepreneurial start-ups and quality of innovation which have emerged in the vicinity of the square since 2010. Both Harvard and MIT, also in Cambridge, are perennially ranked as either the most or among the most highly regarded academic institutions in the world. Massachusetts residents have been described by the World Population Review as having the highest average IQ of all U.S. states, exceeding 104, and the state's public-school students place among the top tier in the world in academic performance. The state has been ranked as one of the top states in the United States for citizens to live in, as well as one of the most expensive.