Isabella of Aragon, Queen of Portugal, Daughter of Isabella I of Castile and Ferdinand II of Aragon (d. 1498)
Isabella, Princess of Asturias (2 October 1470 – 23 August 1498) was the eldest daughter and heir presumptive of King Ferdinand II of Aragon and Queen Isabella I of Castile. She was Queen of Portugal as the wife of King Manuel I from 30 September 1497 until her death the next year.