Ali Maow Maalin, the last natural case of smallpox, develops rash in Merca district, Somalia. The World Health Organization and the Centers for Disease Control and Prevention consider this date the anniversary of the eradication of smallpox, the most spectacular success of vaccination.

Ali Maow Maalin (Somali: Cali Macow Macallin; also Mao Moallim and Mao' Mo'allim; 1954 – 22 July 2013) was a Somali hospital cook and health worker from Merca who is the last person known to have been infected with naturally occurring Variola minor smallpox. He was diagnosed with the disease in October 1977 and made a full recovery. Although he had many contacts, none of them developed the disease, and an aggressive containment campaign was successful in preventing an outbreak. Smallpox was declared to have been eradicated globally by the World Health Organization (WHO) two years later. Maalin was subsequently involved in the successful poliomyelitis eradication campaign in Somalia, and he died of malaria while carrying out polio vaccinations after the re-emergence of the poliovirus in 2013.