Michelangelo begins work on his statue of David.

David is a masterpiece of Renaissance sculpture, created in marble between 1501 and 1504 by the Italian artist Michelangelo. David is a 5.17-metre (17 ft 0 in) marble statue of the Biblical figure David, a favoured subject in the art of Florence.David was originally commissioned as one of a series of statues of prophets to be positioned along the roofline of the east end of Florence Cathedral, but was instead placed in a public square, outside the Palazzo Vecchio, the seat of civic government in Florence, in the Piazza della Signoria, where it was unveiled on 8 September 1504. The statue was moved to the Galleria dell'Accademia, Florence, in 1873, and later replaced at the original location by a replica.

Because of the nature of the figure it represented, the statue soon came to symbolize the defence of civil liberties embodied in the Republic of Florence, an independent city-state threatened on all sides by more powerful rival states and by the hegemony of the Medici family. The eyes of David, with a warning glare, were fixated towards Rome where the Medici family lived.

Michelangelo di Lodovico Buonarroti Simoni (Italian: [mikeˈlandʒelo di lodoˈviːko ˌbwɔnarˈrɔːti siˈmoːni]; 6 March 1475 – 18 February 1564), known simply as Michelangelo (English: ), was an Italian sculptor, painter, architect and poet of the High Renaissance. Born in the Republic of Florence, his work had a major influence on the development of Western art, particularly in relation to the Renaissance notions of humanism and naturalism. He is often considered a contender for the title of the archetypal Renaissance man, along with his rival and elder contemporary, Leonardo da Vinci. Given the sheer volume of surviving correspondence, sketches, and reminiscences, Michelangelo is one of the best-documented artists of the 16th century and several scholars have described Michelangelo as the most accomplished artist of his era.He sculpted two of his best-known works, the Pietà and David, before the age of thirty. Despite holding a low opinion of painting, he also created two of the most influential frescoes in the history of Western art: the scenes from Genesis on the ceiling of the Sistine Chapel in Rome, and The Last Judgment on its altar wall. His design of the Laurentian Library pioneered Mannerist architecture. At the age of 74, he succeeded Antonio da Sangallo the Younger as the architect of St. Peter's Basilica. He transformed the plan so that the western end was finished to his design, as was the dome, with some modification, after his death.

Michelangelo was the first Western artist whose biography was published while he was alive. In fact, two biographies were published during his lifetime. One of them, by Giorgio Vasari, proposed that Michelangelo's work transcended that of any artist living or dead, and was "supreme in not one art alone but in all three."In his lifetime, Michelangelo was often called Il Divino ("the divine one"). His contemporaries often admired his terribilità—his ability to instill a sense of awe in viewers of his art. Attempts by subsequent artists to imitate Michelangelo's impassioned, highly personal style contributed to the rise of Mannerism, a short-lived style and period in Western art following the High Renaissance.