Margaret Chase Smith of Maine becomes the first woman elected to the United States Senate without completing another senator's term, when she defeats Democratic opponent Adrian Scolten.

Margaret Madeline Chase Smith (December 14, 1897 – May 29, 1995) was an American politician. A member of the Republican Party, she served as a U.S. representative (1940–1949) and a U.S. senator (1949–1973) from Maine. She was the first woman to serve in both houses of the United States Congress, and the first woman to represent Maine in either. A moderate Republican, she was among the first to criticize the tactics of Joseph McCarthy in her 1950 speech, "Declaration of Conscience".Smith was a candidate for the Republican presidential nomination in the 1964 election; she was the first woman to be placed in nomination for the presidency at a major party's convention. Upon leaving office, she was the longest-serving female senator in history, a distinction that was not surpassed until January 5, 2011, when Senator Barbara Mikulski from Maryland was sworn in for a fifth term. Smith was ranked as the longest-serving Republican woman in the Senate, a distinction that was not surpassed until January 3, 2021, when Susan Collins, who holds the same Senate seat she previously held, was sworn in for a fifth term.