James Hamilton, 4th Duke of Hamilton, Scottish peer (d. 1712)
Lieutenant General James Hamilton, 4th Duke of Hamilton and 1st Duke of Brandon (11 April 1658 – 15 November 1712) was a

Scottish nobleman, the Premier Peer of Scotland, and Keeper of the Palace of Holyroodhouse. He was a Master of the Great Wardrobe, Master-General of the Ordnance, Ambassador, and Colonel-in-Chief of his regiment. Hamilton was a major investor in the failed Darien Scheme, which cost many of Scotland's ruling class their fortunes, and he played a leading role in the events leading up to the Act of Union in 1707. He died on 15 November 1712 as the result of a celebrated duel in Hyde Park, Westminster, with Charles Mohun, 4th Baron Mohun, over a disputed inheritance.