James McCune Smith, African-American physician, apothecary, abolitionist, and author (d. 1865)
James McCune Smith (April 18, 1813 – November 17, 1865) was an American physician, apothecary, abolitionist, and author who was born in Manhattan. He was the first African American to hold a medical degree and he was graduated at the top in his class at the University of Glasgow in Scotland. After his return to the United States, he became the first African American to run a pharmacy in the nation.

In addition to practicing as a physician for nearly 20 years at the Colored Orphan Asylum in Manhattan, Smith was a public intellectual: he contributed articles to medical journals, participated in learned societies, and wrote numerous essays and articles drawing from his medical and statistical training. He used his training in medicine and statistics to refute common misconceptions about race, intelligence, medicine, and society in general. Invited as a founding member of the New York Statistics Society in 1852, which promoted a new science, he was elected as a member in 1854 of the recently founded American Geographic Society. But he was never admitted to the American Medical Association or local medical associations.

He has been most well known for his leadership as an abolitionist: a member of the American Anti-Slavery Society, with Frederick Douglass he helped start the National Council of Colored People in 1853, the first permanent national organization for blacks. Douglass called Smith "the single most important influence on his life."Smith was one of the Committee of Thirteen, who organized in 1850 in Manhattan to resist the newly passed Fugitive Slave Law by aiding refugee slaves through the Underground Railroad. Other leading abolitionist activists were among his friends and colleagues. From the 1840s, Smith lectured on race and abolitionism and wrote numerous articles to refute racist ideas about black capacities.

Both Smith and his wife were of mixed-race African and European ancestry. As he became economically successful, Smith built a house in a mostly white neighborhood; in the 1860 census he and his family were classified as white, along with their neighbors. In 1850 they were classified as mulatto, when living in a predominately African-American neighborhood.

Smith served for nearly 20 years as the physician at the Colored Orphan Asylum in New York. After it was burned down in July 1863 by a mob in draft riots in Manhattan, in which nearly 100 blacks were killed, Smith moved his family and practice to Brooklyn for their safety. Many other blacks left Manhattan for Brooklyn at the same time. The parents stressed education for their children. In the 1870 census, his widow and children continued to be classified as white.

To escape racial discrimination and have more opportunities, his children passed into white society: the four surviving sons married white spouses; his unmarried daughter lived with a brother. They worked as teachers, a lawyer, and business people. Smith's unique achievements as a pioneering African-American physician were rediscovered by twentieth-century historians. They were relearned by his descendants in the twenty-first century, who identified as white and did not know about him, when a three-times-great-granddaughter took a history class and found his name in her grandmother's family bible. In 2010, several Smith descendants commissioned a new tombstone for his grave in Brooklyn. They gathered to honor him and their African-American ancestry.