The United States declared war on the German Empire on April 6, 1917, nearly three years after World War I started. A ceasefire and Armistice was declared on November 11, 1918. Before entering the war, the U.S. had remained neutral, though it had been an important supplier to the United Kingdom, France, and the other powers of the Allies of World War I.

The U.S. made its major contributions in terms of supplies, raw material, and money, starting in 1917. American soldiers under General of the Armies John Pershing, Commander-in-Chief of the American Expeditionary Force (AEF), arrived at the rate of 10,000 men a day on the Western Front in the summer of 1918. During the war, the U.S. mobilized over 4 million military personnel and suffered the loss of 65,000 soldiers. The war saw a dramatic expansion of the United States government in an effort to harness the war effort and a significant increase in the size of the U.S. Armed Forces.

After a relatively slow start in mobilizing the economy and labor force, by spring 1918, the nation was poised to play a role in the conflict. Under the leadership of President Woodrow Wilson, the war represented the climax of the Progressive Era as it sought to bring reform and democracy to the world. There was substantial public opposition to U.S. entry into the war.

World War I, often abbreviated as WWI or WW1, also known as the First World War and contemporaneously known as the Great War and by other names, was an international conflict that began on 28 July 1914 and ended on 11 November 1918. It involved much of Europe, as well as Russia, the United States and Turkey, and was also fought in the Middle East, Africa and parts of Asia. One of the deadliest conflicts in history, an estimated 9 million were killed in combat, while over 5 million civilians died from occupation, bombardment, hunger or disease. The genocides perpetrated by the Ottomans and the 1918 Spanish flu pandemic spread by the movement of combatants during the war caused many millions of additional deaths worldwide.In 1914, the Great Powers were divided into two opposing alliances: the Triple Entente, consisting of France, Russia, and Britain, and the Triple Alliance, made up of Germany, Austria-Hungary, and Italy. Tensions in the Balkans came to a head on 28 June 1914 following the assassination of Archduke Franz Ferdinand, the Austro-Hungarian heir, by Gavrilo Princip, a Bosnian Serb. Austria-Hungary blamed Serbia and the interlocking alliances involved the Powers in a series of diplomatic exchanges known as the July Crisis. On 28 July, Austria-Hungary declared war on Serbia; Russia came to Serbia's defence and by 4 August, the conflict had expanded to include Germany, France and Britain, along with their respective colonial empires. In November, the Ottoman Empire, Germany and Austria formed the Central Powers, while in April 1915, Italy joined Britain, France, Russia and Serbia as the Allied Powers.

Facing a war on two fronts, German strategy in 1914 was to defeat France, then shift its forces to the East and knock out Russia, commonly known as the Schlieffen Plan. This failed when their advance into France was halted at the Marne; by the end of 1914, the two sides faced each other along the Western Front, a continuous series of trench lines stretching from the Channel to Switzerland that changed little until 1917. By contrast, the Eastern Front was far more fluid, with Austria-Hungary and Russia gaining, then losing large swathes of territory. Other significant theatres included the Middle East, the Alpine Front and the Balkans, bringing Bulgaria, Romania and Greece into the war.

Shortages caused by the Allied naval blockade led Germany to initiate unrestricted submarine warfare in early 1917, bringing the previously neutral United States into the war on 6 April 1917. In Russia, the Bolsheviks seized power in the 1917 October Revolution and made peace in the March 1918 Treaty of Brest-Litovsk, freeing up large numbers of German troops. By transferring these to the Western Front, the German General Staff hoped to win a decisive victory before American reinforcements could impact the war, and launched the March 1918 German spring offensive. Despite initial success, it was soon halted by heavy casualties and ferocious defence; in August, the Allies launched the Hundred Days Offensive and although the German army continued to fight hard, it could no longer halt their advance.Towards the end of 1918, the Central Powers began to collapse; Bulgaria signed an Armistice on 29 September, followed by the Ottomans on 31 October, then Austria-Hungary on 3 November. Isolated, facing revolution at home and an army on the verge of mutiny, Kaiser Wilhelm abdicated on 9 November and the new German government signed the Armistice of 11 November 1918, bringing the fighting to a close. The 1919 Paris Peace Conference imposed various settlements on the defeated powers, the best known being the Treaty of Versailles. The dissolution of the Russian, German, Ottoman and Austro-Hungarian empires led to numerous uprisings and the creation of independent states, including Poland, Czechoslovakia and Yugoslavia. For reasons that are still debated, failure to manage the instability that resulted from this upheaval during the interwar period ended with the outbreak of World War II in 1939.