Following the escalation of the Darfur conflict in the Sudan, Chad brokered negotiations in N'Djamena led to the Humanitarian Ceasefire Agreement between the Sudanese government and the two rebel groups, the Sudanese Justice and Equality Movement (JEM) and the Sudan Liberation Movement/Army (SLM/A) on 8 April 2004, other signatories were Chad and the African Union. The ceasefire came into effect on 11 April 2004.

The National Movement for Reform and Development a group which splintered from the JEM in April did not participate in the cease-fire talks or the agreement. Janjaweed and rebel attacks have continued since the ceasefire.

The African Union formed a Ceasefire Commission (CFC) to monitor observance of the ceasefire.

The War in Darfur, also nicknamed the Land Cruiser War, is a major armed conflict in the Darfur region of Sudan that began in February 2003 when the Sudan Liberation Movement (SLM) and the Justice and Equality Movement (JEM) rebel groups began fighting against the government of Sudan, which they accused of oppressing Darfur's non-Arab population. The government responded to attacks by carrying out a campaign of ethnic cleansing against Darfur's non-Arabs. This resulted in the death of hundreds of thousands of civilians and the indictment of Sudan's president, Omar al-Bashir, for genocide, war crimes, and crimes against humanity by the International Criminal Court.One side of the conflict is mainly composed of the Sudanese military, police and the Janjaweed, a Sudanese militia group whose members are mostly recruited among Arabized indigenous Africans and a small number of Bedouin of the northern Rizeigat; the majority of other Arab groups in Darfur remained uninvolved.

The other side is made up of rebel groups, notably the SLM/A and the JEM, recruited primarily from the non-Arab Muslim Fur, Zaghawa, and Masalit ethnic groups. The African Union and the United Nations also have a joint peacekeeping mission in the region, named UNAMID. Although the Sudanese government publicly denies that it supported the Janjaweed, evidence supports claims that it provided financial assistance and weapons and coordinated joint attacks, many against civilians. Estimates of the number of human casualties range up to several hundred thousand dead, from either combat or starvation and disease. Mass displacements and coercive migrations forced millions into refugee camps or across the border, creating a humanitarian crisis. Former US Secretary of State Colin Powell described the situation as a genocide or acts of genocide.The Sudanese government and the JEM signed a ceasefire agreement in February 2010, with a tentative agreement to pursue peace. The JEM has the most to gain from the talks and could see semi-autonomy much like South Sudan. However, talks were disrupted by accusations that the Sudanese army launched raids and air strikes against a village, violating the Tolu agreement. The JEM, the largest rebel group in Darfur, vowed to boycott negotiations.The August 2019 Draft Constitutional Declaration, signed by military and civilian representatives during the Sudanese Revolution, requires that a peace process leading to a peace agreement be made in Darfur and other regions of armed conflict in Sudan within the first six months of the 39-month transition period to democratic civilian government.A comprehensive peace agreement was signed on 31 August 2020 between the Sudanese authorities and several rebel factions to end armed hostilities.