The Battle of Plymouth was a naval battle in the First Anglo-Dutch War. It took place on 16 August 1652 (26 August 1652 (Gregorian calendar)) and was a short battle, but had the unexpected outcome of a Dutch victory over England. General-at-Sea George Ayscue of the Commonwealth of England attacked an outward bound convoy of the Dutch Republic commanded by Vice-Commodore Michiel de Ruyter. The two commanders had been personal friends before the war.

The Dutch were able to force Ayscue to break off the engagement, and the Dutch convoy sailed safely to the Atlantic while Ayscue sailed to Plymouth for repairs.