The Jacobite rising of 1745, also known as the Forty-five Rebellion or simply the '45 (Scottish Gaelic: Bliadhna Therlaich, [plin hjarl], lit.'The Year of Charles'), was an attempt by Charles Edward Stuart to regain the British throne for his father, James Francis Edward Stuart. It took place during the War of the Austrian Succession, when the bulk of the British Army was fighting in mainland Europe, and proved to be the last in a series of revolts that began in 1689, with major outbreaks in 1708, 1715 and 1719.

Charles launched the rebellion on 19 August 1745 at Glenfinnan in the Scottish Highlands, capturing Edinburgh and winning the Battle of Prestonpans in September. At a council in October, the Scots agreed to invade England after Charles assured them of substantial support from English Jacobites and a simultaneous French landing in Southern England. On that basis, the Jacobite army entered England in early November, reaching Derby on 4 December, where they decided to turn back.

Similar discussions had taken place at Carlisle, Preston and Manchester and many felt they had gone too far already. The invasion route had been selected to cross areas considered strongly Jacobite but the promised English support failed to materialise; they were now outnumbered and in danger of having their retreat cut off. The decision was supported by the vast majority but caused an irretrievable split between Charles and his Scots supporters. Despite victory at Falkirk Muir in January 1746, the Battle of Culloden in April ended the Rebellion and significant backing for the Stuart cause. Charles escaped to France, but was unable to win support for another attempt, and died in Rome in 1788.

Charles Edward Louis John Casimir Sylvester Severino Maria Stuart (20 December 1720 – 30 January 1788) was the elder son of James Francis Edward Stuart, grandson of James II and VII, and the Stuart claimant to the thrones of Great Britain and Ireland after 1766 as Charles III. During his lifetime, he was also known as "the Young Pretender" and "the Young Chevalier"; in popular memory, he is known as Bonnie Prince Charlie. He is best remembered for his role in the 1745 rising; his defeat at Culloden in April 1746 effectively ended the Stuart cause, and subsequent attempts failed to materialise, such as a planned French invasion in 1759. His escape from Scotland after the uprising led to his portrayal as a romantic figure of heroic failure.