The Frankfurter Judengasse ("Jews' Lane" in German) was the Jewish ghetto of Frankfurt and one of the earliest ghettos in Germany. It existed from 1462 until 1811 and was home to Germany's largest Jewish community in early modern times.

At the end of the 19th century, most of the buildings in the Judengasse were demolished. The area suffered major destruction during World War II and reconstruction left no visible signs of the ghetto in today's townscape of Frankfurt.

Post-war usage of the area included a car park, a petrol station and a wholesale flower market. The decision to build an administrative complex triggered a public discussion as to what should be done with the archaeological remains uncovered during the excavation in 1977. The foundations of 19 buildings were found and five of these can be seen at the "Museum Judengasse" which was incorporated into the new building.