Bubonic plague is one of three types of plague caused by the plague bacterium (Yersinia pestis). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. Acral necrosis, the dark discoloration of skin, is another symptom. Occasionally, swollen lymph nodes, known as "buboes," may break open.The three types of plague are the result of the route of infection: bubonic plague, septicemic plague, and pneumonic plague. Bubonic plague is mainly spread by infected fleas from small animals. It may also result from exposure to the body fluids from a dead plague-infected animal. Mammals such as rabbits, hares, and some cat species are susceptible to bubonic plague, and typically die upon contraction. In the bubonic form of plague, the bacteria enter through the skin through a flea bite and travel via the lymphatic vessels to a lymph node, causing it to swell. Diagnosis is made by finding the bacteria in the blood, sputum, or fluid from lymph nodes.Prevention is through public health measures such as not handling dead animals in areas where plague is common. While vaccines against the plague have been developed, the World Health Organization recommends that only high-risk groups, such as certain laboratory personnel and health care workers, get inoculated. Several antibiotics are effective for treatment, including streptomycin, gentamicin, and doxycycline.Without treatment, plague results in the death of 30% to 90% of those infected. Death, if it occurs, is typically within 10 days. With treatment, the risk of death is around 10%. Globally between 2010 and 2015 there were 3,248 documented cases, which resulted in 584 deaths. The countries with the greatest number of cases are the Democratic Republic of the Congo, Madagascar, and Peru.The plague is considered the likely cause of the Black Death that swept through Asia, Europe, and Africa in the 14th century and killed an estimated 50 million people, including about 25% to 60% of the European population. Because the plague killed so many of the working population, wages rose due to the demand for labor. Some historians see this as a turning point in European economic development. The disease is also considered to have been responsible for the Plague of Justinian, originating in the Eastern Roman Empire in the 6th century CE, as well as the third epidemic, affecting China, Mongolia, and India, originating in the Yunnan Province in 1855. The term bubonic is derived from the Greek word , meaning "groin".

Mainz (; German: [maɪ̯nt͡s] (listen)) is the capital and largest city of Rhineland-Palatinate (German: Rheinland-Pfalz), Germany.

Mainz is located on the left-bank of the Rhine, opposite where the Main joins the Rhine. Downstream of this confluence, the Rhine flows to the north-west, with Mainz on the left-bank, and Wiesbaden, the capital of the neighbouring state Hesse, on the right-bank.

Mainz is an independent city with a population of 218,578 (as of 2019) and forms part of the Frankfurt Rhine-Main Metropolitan Region.Mainz was founded by the Romans in the 1st century BC as a military fortress on the northernmost frontier of the empire and provincial capital of Germania Superior. Mainz became an important city in the 8th century AD as part of the Holy Roman Empire, capital of the Electorate of Mainz and seat of the Archbishop-Elector of Mainz, the Primate of Germany. Mainz is famous as the birthplace of Johannes Gutenberg, the inventor of a movable-type printing press, who in the early 1450s manufactured his first books in the city, including the Gutenberg Bible. Mainz was heavily damaged in World War II; more than 30 air raids destroyed most of the historic buildings.

Mainz is notable as a transport hub, for wine production, and for its many rebuilt historic buildings.