The Bertha Benz Memorial Route is a German tourist and theme route in Baden-Wrttemberg and member of the European Route of Industrial Heritage. It opened in 2008 and follows the tracks of the world's first long distance road trip by a vehicle powered with an internal combustion engine, in 1888.

Bertha Benz (German: [ˈbɛʁta ˈbɛnts] (listen); née Cäcilie Bertha Ringer; 3 May 1849 – 5 May 1944) was a German automotive pioneer and inventor. She was the business partner and wife of automobile inventor Carl Benz. On 5 August 1888, she was the first person to drive an internal-combustion-engined automobile over a long distance, field testing the Benz Patent-Motorwagen, inventing brake lining and solving several practical issues during the journey of 105 km (65 miles). In doing so, she brought the Patent-Motorwagen worldwide attention and got the company its first sales.