USS Red Rover (1859) was a 650-ton Confederate States of America steamer that the United States Navy captured. After refitting the vessel, the Union used it as a hospital ship during the American Civil War.

Red Rover became the U.S. Navy's first hospital ship, serving the Mississippi Squadron until the end of the American Civil War. Her medical complement included nurses from the Catholic order Sisters of the Holy Cross, the first volunteer females to serve on board a Navy ship as females. In addition to caring for and transporting sick and wounded men, she provided medical supplies to Navy ships along the Western Rivers.