Dave Henderson, American baseball player and sportscaster (b. 1958)
David Lee Henderson (July 21, 1958 – December 27, 2015), nicknamed "Hendu", was an American professional baseball player. He played in Major League Baseball (MLB) for the Seattle Mariners, Boston Red Sox, San Francisco Giants, Oakland Athletics, and Kansas City Royals during his 14-year career, primarily as an outfielder.

Henderson is best remembered for the two-out, two-strike home run he hit in the top of the ninth inning in Game 5 of the 1986 American League Championship Series. He helped his teams reach the World Series four times during his career—Boston in 1986 and Oakland from 1988 to 1990, with Oakland winning the championship in 1989. His uncle Joe Henderson appeared in 16 MLB games as a pitcher during the mid-1970s.