James Moore (c. 1650 1706) was an Irish colonial administrator and military officer who served as the governor of Carolina from 1700 to 1703. He is best known for leading several invasions of Spanish Florida during Queen Anne's War, including attacks in 1704 and 1706 which wiped out most of the Spanish missions in Florida. He captured and brought back to Carolina as slaves thousands of Apalachee Indians.

Queen Anne's War (1702–1713) was the second in a series of French and Indian Wars fought in North America involving the colonial empires of Great Britain, France, and Spain; it took place during the reign of Anne, Queen of Great Britain. In Europe, it is generally viewed as the American theater of the War of the Spanish Succession; in the Americas, it is more commonly viewed as a standalone conflict. It is also known as the Third Indian War. In France it was known as the Second Intercolonial War.