USS Jacob Jones (Destroyer No. 61/DD-61) was a Tucker-class destroyer built for the United States Navy prior to the American entry into World War I. The ship was the first U.S. Navy vessel named in honor of Jacob Jones.

Jacob Jones was laid down by the New York Shipbuilding of Camden, New Jersey, in August 1914 and launched in May of the following year. The ship was a little more than 315 feet (96 m) in length, just over 30 feet (9.1 m) abeam, and had a standard displacement of 1,090 long tons (1,110 t). She was armed with four 4-inch (10 cm) guns and had eight 21 inch (533 mm) torpedo tubes. Jacob Jones was powered by a pair of steam turbines that propelled her at up to 30 knots (56 km/h).

After her February 1916 commissioning, Jacob Jones conducted patrols off the New England coast. After the United States entered World War I in April 1917, Jacob Jones was sent overseas. Patrolling the Irish Sea out of Queenstown, Ireland, Jacob Jones rescued the survivors of several ships, picking up over 300 from the sunken Armed merchant cruiser Orama.

On 6 December, Jacob Jones was steaming independently from Brest, France, for Queenstown, when she was torpedoed and sunk by German submarine U-53 with the loss of 66 men, becoming the first United States destroyer sunk by enemy action. Jacob Jones sank in eight minutes without issuing a distress call; the German submarine commander, Kapitänleutnant Hans Rose, after taking two badly injured Jacob Jones crewmen aboard his submarine, radioed the U.S. base at Queenstown with the coordinates for the survivors. The Veterans of Foreign Wars post in Dedham, Massachusetts is named for the ship.