Lucrezia de' Medici, Duchess of Ferrara (d. 1561)
Lucrezia de' Medici (14 February 1545 – 21 April 1561), was a member of the House of Medici and by marriage Duchess consort of Ferrara, Modena and Reggio during 1558–1561.

Married to the intended husband of her elder sister Maria, who died young, her marriage was short and unhappy. The Duchess died of pulmonary tuberculosis, but almost immediately after her death there were rumors that she had been poisoned on the orders of her husband. That suspicion inspired the English poet Robert Browning to create a dramatic monologue in verse "My Last Duchess" (1842).