The Kingdom of Granada (; Spanish: Reino de Granada) was a territorial jurisdiction of the Crown of Castile from the conclusion of the Reconquista in 1492 until Javier de Burgos' provincial division of Spain in 1833. This was a "kingdom" ("reino") in the second sense given by the Diccionario de la lengua espaola de la Real Academia Espaola: the Crown of Castile consisted of several such kingdoms. Its extent is detailed in Gelo del Cabildo's 1751 Respuestas Generales del Catastro de Ensenada (175054), which was part of the documentation of a census. Like the other kingdoms within Spain, the Kingdom of Granada was abolished by the 1833 territorial division of Spain.

After the Granada War ended 2 January 1492, the old Muslim-ruled Emirate of Granada became part of the Crown of Castile. The kingdom was the location of a Muslim rebellion in 1499-1501 and after the Muslims were defeated and forcibly converted, a Morisco rebellion in 1568-1571. Following the annexation, The city of Granada, which had been the last center of Muslim power in the Iberian Peninsula, lost its political importance and even much of its economic importance, and entered a long period of decline. The European discovery of America gave preeminence to Seville, the only important inland port, which by the 16th century had become the principal city not only of Andalusia, but of all Spain. Nonetheless, Granada continued to play a significant institutional role: it was one of the seventeen cities with a vote in the Cortes de Castilla, the Granada Cathedral was the seat of an archdiocese and the Royal Chancery of Granada was the highest judicial court for half of the Crown of Castile, equaled only by a corresponding institution in Valladolid.

The difficulties of religious and ethnic integration of the Moriscos (former Muslims who had converted to Christianity) with the now-dominant Old Christians resulted in the unsuccessful, harshly repressed Morisco Revolt of 15681571. The Moriscos were initially dispersed in the Castilian interior, then expelled outright from Spain in 1609.

Today, all the territory of the Kingdom of Granada is part of the territory of the autonomous community of Andalusia.

The Tribunal of the Holy Office of the Inquisition (Spanish: Tribunal del Santo Oficio de la Inquisición), commonly known as the Spanish Inquisition (Spanish: Inquisición española), was established in 1478 by the Catholic Monarchs, King Ferdinand II of Aragon and Queen Isabella I of Castile. It was intended to maintain Catholic orthodoxy in their kingdoms and to replace the Medieval Inquisition, which was under Papal control. It became the most substantive of the three different manifestations of the wider Catholic Inquisition along with the Roman Inquisition and Portuguese Inquisition. The "Spanish Inquisition" may be defined broadly as operating in Spain and in all Spanish colonies and territories, which included the Canary Islands, the Kingdom of Naples, and all Spanish possessions in North, Central, and South America. According to modern estimates, around 150,000 people were prosecuted for various offences during the three-century duration of the Spanish Inquisition, of whom between 3,000 and 5,000 were executed (~2.7% of all cases).The Inquisition was originally intended primarily to identify heretics among those who converted from Judaism and Islam to Catholicism. The regulation of the faith of newly converted Catholics was intensified after the royal decrees issued in 1492 and 1502 ordering Jews and Muslims to convert to Catholicism or leave Castile, resulting in hundreds of thousands of forced conversions, the persecution of conversos and moriscos, and the mass expulsions of Jews and of Muslims from Spain. The Inquisition was not definitively abolished until 1834, during the reign of Isabella II, after a period of declining influence in the preceding century.