The Boeing B-17 Flying Fortress is a four-engined heavy bomber developed in the 1930s for the United States Army Air Corps (USAAC). Competing against Douglas and Martin for a contract to build 200 bombers, the Boeing entry (prototype Model 299/XB-17) outperformed both competitors and exceeded the Air Corps' performance specifications. Although Boeing lost the contract (to the Douglas B-18 Bolo) because the prototype crashed, the Air Corps ordered 13 more B-17s for further evaluation. From its introduction in 1938, the B-17 Flying Fortress evolved through numerous design advances, becoming the third-most produced bomber of all time, behind the four-engined Consolidated B-24 Liberator and the multirole, twin-engined Junkers Ju 88.

The B-17 was primarily employed by the USAAF in the daylight strategic bombing campaign of World War II against German industrial, military and civilian targets. The United States Eighth Air Force, based at many airfields in central, eastern and southern England, and the Fifteenth Air Force, based in Italy, complemented the RAF Bomber Command's night-time area bombing in the Combined Bomber Offensive to help secure air superiority over the cities, factories and battlefields of Western Europe in preparation for the invasion of France in 1944. The B-17 also participated to a lesser extent in the Pacific War, early in World War II, where it conducted raids against Japanese shipping and airfields.From its prewar inception, the USAAC (by June 1941, the USAAF) promoted the aircraft as a strategic weapon; it was a relatively fast, high-flying, long-range bomber with heavy defensive armament at the expense of bombload. It developed a reputation for toughness based upon stories and photos of badly damaged B-17s safely returning to base. The B-17 dropped more bombs than any other U.S. aircraft in World War II. Of approximately 1.5 million tons of bombs dropped on Nazi Germany and its occupied territories by U.S. aircraft, over 640 000 tons (42.6%) were dropped from B-17s. In addition to its role as a bomber, the B-17 was also employed as a transport, antisubmarine aircraft, drone controller, and search-and-rescue aircraft.

As of October 2019, nine aircraft remain airworthy, though none of them were ever flown in combat. Dozens more are in storage or on static display. The oldest of these is a D-series flown in combat in the Pacific on the first day of the United States' involvement in World War II.

Berlin, then the capital of Nazi Germany, was subject to 363 air raids during the Second World War. It was bombed by the RAF Bomber Command between 1940 and 1945, by the USAAF Eighth Air Force between 1943 and 1945, and the French Air Force between 1944 and 1945, as part of the Allied campaign of strategic bombing of Germany. It was also attacked by aircraft of the Red Air Force, in 1941 and particularly in 1945 as Soviet forces closed on the city. British bombers dropped 45,517 tons of bombs, while American aircraft dropped 23,000 tons. As the bombings continued, more and more people fled the city. By May 1945, 1.7 million people (40% of the population) had fled.