Unigenitus (named for its Latin opening words Unigenitus dei filius, or "Only-begotten son of God") is an apostolic constitution in the form of a papal bull promulgated by Pope Clement XI in 1713. It opened the final phase of the Jansenist controversy in France. Unigenitus condemned 101 propositions of Pasquier Quesnel as:

false, captious, ill-sounding, offensive to pious ears, scandalous, pernicious, rash, injurious to the Church and its practices, contumelious to Church and State, seditious, impious, blasphemous, suspected and savouring of heresy, favouring heretics, heresy, and schism, erroneous, bordering on heresy, often condemned, heretical, and reviving various heresies, especially those contained in the famous propositions of Jansenius.

Pope Clement VI (Latin: Clemens VI; 1291 – 6 December 1352), born Pierre Roger, was head of the Catholic Church from 7 May 1342 to his death in 1352. He was the fourth Avignon pope. Clement reigned during the first visitation of the Black Death (1348–1350), during which he granted remission of sins to all who died of the plague.

Roger steadfastly resisted temporal encroachments on the Church's ecclesiastical jurisdiction and, as Clement VI, entrenched French dominance of the Church and opened its coffers to enhance the regal splendour of the Papacy. He recruited composers and music theorists for his court, including figures associated with the then-innovative Ars Nova style of France and the Low Countries.