Alaska Airlines Flight 261 was an Alaska Airlines flight of a McDonnell Douglas MD-83 plane that crashed into the Pacific Ocean on January 31, 2000, roughly 2.7 miles (4.3 km; 2.3 nmi) north of Anacapa Island, California, following a catastrophic loss of pitch control, killing all 88 people on board: two pilots, three cabin crew members, and 83 passengers. The flight was a scheduled international passenger flight from Licenciado Gustavo Díaz Ordaz International Airport in Puerto Vallarta, Jalisco, Mexico, to Seattle–Tacoma International Airport in Seattle, Washington, United States, with an intermediate stop at San Francisco International Airport in San Francisco, California.

The subsequent investigation by the National Transportation Safety Board (NTSB) determined that inadequate maintenance led to excessive wear and eventual failure of a critical flight control system during flight. The probable cause was stated to be "a loss of airplane pitch control resulting from the in-flight failure of the horizontal stabilizer trim system jackscrew assembly's trapezoidal nut threads. The thread failure was caused by excessive wear resulting from Alaska Airlines' insufficient lubrication of the jackscrew assembly." For their heroic efforts to save the plane the pilots were posthumously awarded and commemorated. The accident served as an inspiration for the fictionalized crash landing depicted in the 2012 movie Flight starring Denzel Washington.