The House of Grimaldi ( grim-AWL-dee, also UK: -AL-, US: -AHL-, Italian: [rimaldi]) is the current reigning house of the Principality of Monaco. The house was founded in 1160 by Grimaldo Canella in Genoa and became the ruling house of Monaco when Francesco Grimaldi captured Monaco in 1297. The House of Grimaldi has produced every Prince of Monaco. During much of the Ancien Rgime, the family resided in the French court, where from 1642 to 1715 they used the title of Duke of Valentinois.

The current head of the house is Albert II of Monaco, Sovereign Prince of Monaco, who is the son and successor of Prince Rainier III and the Princess consort Grace of Monaco, formerly known as Grace Kelly.

Francesco Grimaldi (French: François; English: Francis), called il Malizia (from Italian: "the malicious"), was the Genoese leader of the Guelphs who captured the Rock of Monaco on the night of 8 January 1297. He was the son of Guglielmo Grimaldi by his wife Giacobina or Giacoba, a Genoese noble.