The Great Railroad Strike of 1922, commonly known as the Railway Shopmen's Strike, was a nationwide strike of railroad workers in the United States. Launched on July 1, 1922, by seven of the sixteen railroad labor organizations in existence at the time, the strike continued into the month of August before collapsing.

At least ten people, most of them strikers or family members, were killed in connection with the strike. The collective action of some 400,000 workers in the summer of 1922 was the largest railroad work stoppage since the American Railway Union's Pullman Strike of 1894 and the biggest American strike of any kind since the Great Steel Strike of 1919.