Antonio de Mendoza, Spanish politician, 1st Viceroy of New Spain (b. 1495)
Antonio de Mendoza y Pacheco (, Spanish: [anˈtonjo ðe menˈdosa]; 1495 – July 21, 1552) was the first Viceroy of New Spain, serving from November 14, 1535 to November 25, 1550, and the third Viceroy of Peru, from September 23, 1551, until his death on July 21, 1552.

Mendoza was born at Alcalá la Real (Jaén, Spain), the son of the 2nd Count of Tendilla, Íñigo López de Mendoza y Quiñones, and Francisca Pacheco. He was married to María Ana de Trujillo de Mendoza.