Mariner 1, built to conduct the first American planetary flyby of Venus, was the first spacecraft of NASA's interplanetary Mariner program. Developed by Jet Propulsion Laboratory, and originally planned to be a purpose-built probe launched summer 1962, Mariner 1's design was changed when the Centaur proved unavailable at that early date. Mariner 1 (and its sibling spacecraft, Mariner 2), were then adapted from the lighter Ranger lunar spacecraft. Mariner 1 carried a suite of experiments to determine the temperature of Venus as well to measure magnetic fields and charged particles near the planet and in interplanetary space.

Mariner 1 was launched by an Atlas-Agena rocket from Cape Canaveral's Pad 12 on 22 July 1962. Shortly after liftoff, errors in communication between the rocket and its ground-based guidance systems caused the rocket to veer off course, and it had to be destroyed by range safety. The errors were soon traced to the omission of a hyphen-shaped symbol from one of the guidance program characters. Science-fiction author Arthur C. Clarke described the error as "the most expensive hyphen in history".



The Mariner program was conducted by the American space agency NASA to explore other planets. Between 1962 and late 1973, NASA’s Jet Propulsion Laboratory (JPL) designed and built 10 robotic interplanetary probes named Mariner to explore the inner Solar System - visiting the planets Venus, Mars and Mercury for the first time, and returning to Venus and Mars for additional close observations.The program included a number of firsts, including the first planetary flyby, the first planetary orbiter, and the first gravity assist maneuver. Of the 10 vehicles in the Mariner series, seven were successful, forming the starting point for many subsequent NASA/JPL space probe programs. The planned Mariner Jupiter-Saturn vehicles were adapted into the Voyager program, while the Viking program orbiters were enlarged versions of the Mariner 9 spacecraft. Later Mariner-based spacecraft include Galileo and Magellan, while the second-generation Mariner Mark II series evolved into the Cassini–Huygens probe.

The total cost of the Mariner program was approximately $554 million.