Fort Niagara is a fortification originally built by New France to protect its interests in North America, specifically control of access between the Niagara River and Lake Ontario, the easternmost of the Great Lakes. The fort is on the river's eastern bank at its mouth on Lake Ontario. Youngstown, New York, later developed near here.

The British took over the fort in 1759 during the French and Indian War. Although the United States was ostensibly ceded the fort after it gained independence in the American Revolutionary War, the British stayed until 1796, after signing of the Jay Treaty that settled the northern border. Although the US Army deactivated the fort in 1963, the Coast Guard continues to have a presence here. A non-profit group operates the fort and grounds as a state park and preserves it in part as a museum and site for historical re-enactments. It is also a venue for special events related to the region's history.

The French and Indian War (1754–1763) was a theater of the Seven Years' War, which pitted the North American colonies of the British Empire against those of the French, each side being supported by various Native American tribes. At the start of the war, the French colonies had a population of roughly 60,000 settlers, compared with 2 million in the British colonies. The outnumbered French particularly depended on the natives.Two years into the French and Indian War, in 1756, Great Britain declared war on France, beginning the worldwide Seven Years' War. Many view the French and Indian War as being merely the American theater of this conflict; however, in the United States the French and Indian War is viewed as a singular conflict which was not associated with any European war. French Canadians call it Guerre de la Conquête ('War of the Conquest').The British colonists were supported at various times by the Iroquois, Catawba, and Cherokee tribes, and the French colonists were supported by Wabanaki Confederacy member tribes Abenaki and Mi'kmaq, and the Algonquin, Lenape, Ojibwa, Ottawa, Shawnee, and Wyandot tribes. Fighting took place primarily along the frontiers between New France and the British colonies, from the Province of Virginia in the south to Newfoundland in the north. It began with a dispute over control of the confluence of the Allegheny River and Monongahela River called the Forks of the Ohio, and the site of the French Fort Duquesne at the location that later became Pittsburgh, Pennsylvania. The dispute erupted into violence in the Battle of Jumonville Glen in May 1754, during which Virginia militiamen under the command of 22-year-old George Washington ambushed a French patrol.In 1755, six colonial governors met with General Edward Braddock, the newly arrived British Army commander, and planned a four-way attack on the French. None succeeded, and the main effort by Braddock proved a disaster; he lost the Battle of the Monongahela on July 9, 1755, and died a few days later. British operations failed in the frontier areas of the Province of Pennsylvania and the Province of New York during 1755–57 due to a combination of poor management, internal divisions, effective Canadian scouts, French regular forces, and Native warrior allies. In 1755, the British captured Fort Beauséjour on the border separating Nova Scotia from Acadia, and they ordered the expulsion of the Acadians (1755–64) soon afterwards. Orders for the deportation were given by Commander-in-Chief William Shirley without direction from Great Britain. The Acadians were expelled, both those captured in arms and those who had sworn the loyalty oath to the King. Natives likewise were driven off the land to make way for settlers from New England.The British colonial government fell in the region of Nova Scotia after several disastrous campaigns in 1757, including a failed expedition against Louisbourg and the Siege of Fort William Henry; this last was followed by the Natives torturing and massacring their colonial victims. William Pitt came to power and significantly increased British military resources in the colonies at a time when France was unwilling to risk large convoys to aid the limited forces that they had in New France, preferring to concentrate their forces against Prussia and its allies who were now engaged in the Seven Years' War in Europe. The conflict in Ohio ended in 1758 with the British–American victory in the Ohio Country. Between 1758 and 1760, the British military launched a campaign to capture French Canada. They succeeded in capturing territory in surrounding colonies and ultimately the city of Quebec (1759). The following year the British were victorious in the Montreal Campaign in which the French ceded Canada in accordance with the Treaty of Paris (1763).

France also ceded its territory east of the Mississippi to Great Britain, as well as French Louisiana west of the Mississippi River to its ally Spain in compensation for Spain's loss to Britain of Spanish Florida. (Spain had ceded Florida to Britain in exchange for the return of Havana, Cuba.) France's colonial presence north of the Caribbean was reduced to the islands of Saint Pierre and Miquelon, confirming Great Britain's position as the dominant colonial power in northern America.