25143 Itokawa (provisional designation 1998 SF36) is a sub-kilometer near-Earth object of the Apollo group and a potentially hazardous asteroid. It was discovered by the LINEAR program in 1998 and later named after Japanese rocket engineer Hideo Itokawa. The peanut-shaped S-type asteroid has a rotation period of 12.1 hours and measures approximately 330 meters (1,100 feet) in diameter. Due to its low density and high porosity, Itokawa is considered to be a rubble pile, consisting of numerous boulders of different sizes rather than of a single solid body.

It was the first asteroid to be the target of a sample return mission, the Japanese space probe Hayabusa, which collected more than 1500 regolith dust particles from the asteroid's surface in 2005. After its return to Earth in 2010, the mineralogy, petrography, chemistry, and isotope ratios of these particles have been studied in detail, providing insights into the evolution of the Solar System. Itokawa is the smallest asteroid ever photographed and visited by a spacecraft.

Hayabusa (Japanese: はやぶさ, "Peregrine falcon") was a robotic spacecraft developed by the Japan Aerospace Exploration Agency (JAXA) to return a sample of material from a small near-Earth asteroid named 25143 Itokawa to Earth for further analysis.

Hayabusa, formerly known as MUSES-C for Mu Space Engineering Spacecraft C, was launched on 9 May 2003 and rendezvoused with Itokawa in mid-September 2005. After arriving at Itokawa, Hayabusa studied the asteroid's shape, spin, topography, color, composition, density, and history. In November 2005, it landed on the asteroid and collected samples in the form of tiny grains of asteroidal material, which were returned to Earth aboard the spacecraft on 13 June 2010.

The spacecraft also carried a detachable minilander, MINERVA, which failed to reach the surface.