The Great Siege of Malta (Maltese: L-Assedju l-Kbir) occurred in 1565 when the Ottoman Empire attempted to conquer the island of Malta, then held by the Knights Hospitaller. The siege lasted nearly four months, from 18 May to 11 September 1565.

The Knights Hospitaller had been headquartered in Malta since 1530, after being driven out of Rhodes, also by the Ottomans, in 1522, following the siege of Rhodes. The Ottomans first attempted to take Malta in 1551 but failed. In 1565, Suleiman the Magnificent, the Ottoman Sultan, made a second attempt to take Malta. The Knights, who numbered around 500 together with approximately 6,000 footsoldiers, withstood the siege and repelled the invaders. This victory became one of the most celebrated events of sixteenth-century Europe, to the point that Voltaire said: "Nothing is better known than the siege of Malta." It undoubtedly contributed to the eventual erosion of the European perception of Ottoman invincibility, although the Mediterranean continued to be contested between Christian coalitions and the Muslim Turks for many years.The siege was the climax of an escalating contest between the Christian alliances and the Islamic Ottoman Empire for control of the Mediterranean, a contest that included the Turkish attack on Malta in 1551, the Ottoman destruction of an allied Christian fleet at the Battle of Djerba in 1560, and the decisive Ottoman defeat at the Battle of Lepanto in 1571.

Dragut (Turkish: Turgut Reis) (1485 – 23 June 1565), known as "The Drawn Sword of Islam", was a Muslim Ottoman naval commander, governor, and noble, of Turkish or Greek descent. Under his command, the Ottoman Empire's maritime power was extended across North Africa. Recognized for his military genius, and as being among "the most dangerous" of corsairs, Dragut has been referred to as "the greatest pirate warrior of all time", "undoubtedly the most able of all the Turkish leaders", and "the uncrowned king of the Mediterranean". He was described by a French admiral as "A living chart of the Mediterranean, skillful enough on land to be compared to the finest generals of the time. No one was more worthy than he to bear the name of king".In addition to serving as Admiral and Corsair in the Ottoman Empire's Navy under Suleiman the Magnificent, Dragut was also appointed Bey of Algiers and Djerba, Beylerbey of the Mediterranean, as well as Bey, and subsequently Pasha, of Tripoli. While serving as Pasha of Tripoli, Dragut constructed great feats in the city, making it one of the most impressive to behold along all the North African Coast.