The Organization of Afro-American Unity (OAAU) was a Pan-Africanist organization founded by Malcolm X in 1964. The OAAU was modeled on the Organization of African Unity, which had impressed Malcolm X during his visit to Africa in April and May 1964. The purpose of the OAAU was to fight for the human rights of African Americans and promote cooperation among Africans and people of African descent in the Americas.

Malcolm X announced the establishment of the OAAU at a public meeting in New York's Audubon Ballroom on June 28, 1964. He had written the group's charter with John Henrik Clarke, Albert Cleage, Jesse Gray, and Gloria Richardson, among others. In a memo dated July 2, 1964, FBI Director J. Edgar Hoover described the nascent OAAU as a threat to the national security of the United States.Malcolm X, along with John Henrik Clarke, wrote the following into the Organization of Afro-American Unity (OAAU) Basic Unity Program:

Restoration: "In order to release ourselves from the oppression of our enslavers then, it is absolutely necessary for the Afro-American to restore communication with Africa."

Reorientation: "We can learn much about Africa by reading informative books and by listening to the experiences of those who have traveled there."

Education: "The Organization of Afro-American Unity will devise original educational methods and procedures which will liberate the minds of our children. We will ... encourage qualified Afro-Americans to write and publish the textbooks needed to liberate our minds ... educating them [our children] at home."

Economic Security: "After the Emancipation Proclamation ... it was realized that the Afro-American constituted the largest homogeneous ethnic group with a common origin and common group experience in the United States and, if allowed to exercise economic or political freedom, would in a short period of time own this country. We must establish a technician bank. We must do this so that the newly independent nations of Africa can turn to us who are their brothers for the technicians they will need now and in the future."

Self Defense: "In order to enslave a people and keep them subjugated, their right to self defense must be denied. We encourage the Afro-Americans to defend themselves against the wanton attacks of the racist aggressors whose sole aim is to deny us the guarantee of the United Nations Charter of Human Rights and of the Constitution of the United States."The OAAU pushed for black control of every aspect of the black community. At the founding rally, Malcolm X stated that the organization's principal concern was the human rights of blacks, but that it would also focus on voter registration, school boycotts, rent strikes, housing rehabilitation, and social programs for addicts, unwed mothers, and troubled children. Malcolm X saw the OAAU as a way of "un-brainwashing" black people, ridding them of the lies they had been told about themselves and their culture.

On July 17, 1964, Malcolm X was welcomed to the second meeting of the Organisation of African Unity in Cairo as a representative of the OAAU.When a reporter asked whether white people could join the OAAU, Malcolm X said, "Definitely not." Then he added, "If John Brown were still alive, we might accept him."

Malcolm X (born Malcolm Little, later Malik el-Shabazz; May 19, 1925 – February 21, 1965) was an African-American Muslim minister and human rights activist who was a prominent figure during the civil rights movement. A spokesman for the Nation of Islam until 1964, he was a vocal advocate for black empowerment and the promotion of Islam within the black community.

Malcolm spent his adolescence living in a series of foster homes or with relatives after his father's death and his mother's hospitalization. He engaged in several illicit activities, eventually being sentenced to 10 years in prison in 1946 for larceny and breaking and entering. In prison he joined the Nation of Islam (adopting the name Malcolm X to symbolize his unknown African ancestral surname) and after his parole in 1952 quickly became one of the organization's most influential leaders. He was the public face of the organization for a dozen years, advocating for black empowerment and separation of black and white Americans, and criticizing Martin Luther King Jr. and the mainstream civil rights movement for its emphasis on nonviolence and racial integration. Malcolm X also expressed pride in some of the Nation's social welfare achievements, such as its free drug rehabilitation program. Throughout his life, beginning in the 1950s, Malcolm X endured surveillance from the Federal Bureau of Investigation (FBI).

In the 1960s, Malcolm X began to grow disillusioned with the Nation of Islam, as well as with its leader Elijah Muhammad. He subsequently embraced Sunni Islam and the civil rights movement after completing the Hajj to Mecca, and became known as "el-Hajj Malik el-Shabazz". After a brief period of travel across Africa, he publicly renounced the Nation of Islam and founded the Islamic Muslim Mosque, Inc. (MMI) and the Pan-African Organization of Afro-American Unity (OAAU). Throughout 1964, his conflict with the Nation of Islam intensified, and he was repeatedly sent death threats. On February 21, 1965, he was assassinated in New York City. Three Nation members were charged with the murder and given indeterminate life sentences; in 2021 two of the convictions were vacated. Speculation about the assassination and whether it was conceived or aided by leading or additional members of the Nation, or with law enforcement agencies, have persisted for decades after the shooting.

A controversial figure accused of preaching racism and violence, Malcolm X is also a widely celebrated figure within African-American and Muslim American communities for his pursuit of racial justice. He was posthumously honored with Malcolm X Day, on which he is commemorated in various cities across the United States. Hundreds of streets and schools in the U.S. have been renamed in his honor, while the Audubon Ballroom, the site of his assassination, was partly redeveloped in 2005 to accommodate the Malcolm X and Dr. Betty Shabazz Memorial and Educational Center.