The Maest, or Maest of Duccio is an altarpiece composed of many individual paintings commissioned by the city of Siena in 1308 from the artist Duccio di Buoninsegna and is his most famous work. The front panels make up a large enthroned Madonna and Child with saints and angels, and a predella of the Childhood of Christ with prophets. The reverse has the rest of a combined cycle of the Life of the Virgin and the Life of Christ in a total of forty-three small scenes; several panels are now dispersed or lost. The base of the panel has an inscription that reads (in translation): "Holy Mother of God, be thou the cause of peace for Siena and life to Duccio because he painted thee thus." Though it took a generation for its effect to be truly felt, Duccio's Maest set Italian painting on a course leading away from the hieratic representations of Byzantine art towards more direct presentations of reality.

Duccio di Buoninsegna (UK: DOO-chee-oh, Italian: [ˈduttʃo di ˌbwɔninˈseɲɲa]; c. 1255–1260 – c. 1318–1319) was an Italian painter active in Siena, Tuscany, in the late 13th and early 14th century. He was hired throughout his life to complete many important works in government and religious buildings around Italy. Duccio is considered one of the greatest Italian painters of the Middle Ages, and is credited with creating the painting styles of Trecento and the Sienese school. He also contributed significantly to the Sienese Gothic style.